Two plus signs of glucose in urine test suggest that the patient may have diabetes mellitus. The presence of glucose in urine is generally seen in two situations, the first is the presence of diabetes in patients, due to high blood glucose exceeds the reabsorption capacity of the kidneys, and can be detected in the urine, this condition can cause complications of diabetes, acute complications are the above mentioned diabetic ketoacidosis, etc., there are also chronic complications such as diabetic peripheral neuropathy. The other is damage to the renal tubules, such as hypertensive nephropathy, where the renal tubular reabsorption capacity is impaired although the blood sugar is not very high, but glucose can also appear in the urine, and this condition will gradually develop into chronic renal failure. It is important to monitor blood glucose when there is a plus sign in the urine test, and to look for a history of disease that can cause tubular damage such as hypertension.