Mesotherapy is a minimally invasive technique in which organs and tissues developed and differentiated in the mesoderm are studied, analyzed and treated by puncturing the skin and then injecting intracutaneous or subcutaneous some trace substances, a mixture of natural plant extracts, homeopathic factors, drugs, vitamins and trace bioactive substances, which are quickly, accurately and evenly delivered to the area to be improved and can improve the skin’s ability to heal itself. thus achieving the purpose of treatment, beauty and anti-aging. This approach solves many of the disadvantages of traditional cosmetic methods, such as most of the active ingredients can only penetrate the epidermal stratum corneum or the cosmetic effect is not significant enough, and it is also easy to cause systemic toxic side effects. It should be noted that mesoesthetic does not use real needles to pierce the skin, but rather intensifies penetration by spot pressing and injecting very low doses of drugs in the lesion area to avoid systemic adverse reactions. The effect mainly depends on the selection and compounding of the drug, the site of administration, the depth of injection, the grasp of the indications and the operator’s mastery of the technique. Beauty seekers must choose a regular hospital for treatment, which is generally non-invasive and painless, and rarely has side effects.