The difference between Cistanchis Kidney Pellet and Six-flavored Digoxigenin Pill lies in the composition, efficacy, and effects of the drugs. 1. Different composition: Cistanches Kidney Supplement is composed of Poria, Psyllium, Morinda citrifolia, and Morinda citrifolia; Liuwei Di Huang Wan is composed of Radix Rehmanniae Praeparata, Rhizoma Dioscoreae, Rhizoma Dioscoreae, and Rhizoma Zedoariae, and so on. 2. Difference in efficacy: Cistanches Kidney Supplement Pellets have the effect of tonifying the kidney and replenishing essence; Six-flavored Digoxigenin Pill has the effect of nourishing yin and tonifying the kidney. 3. Different effects: Cistanches Kidney Pellets is used for kidney qi deficiency, weakness of waist and knees, memory loss, dizziness, tinnitus, weakness of limbs, etc. Liu Wei Di Huang Wan is used for kidney yin deficiency, tidal fever (a burst of heat, feeling that the heat is penetrating from inside the bones to the outside), spermatorrhea, night sweating (abnormal sweating after falling asleep, but stopping sweating after waking up). The adverse reactions, contraindications and precautions of Cistanches Kidney Granules are not clear at present; the adverse reactions and contraindications of Six-flavored Digoxigenin Pill are not clear at present, and spicy food should be avoided when taking the drug. If there is a need for medication, it should be used under the guidance of a doctor, and should not be used blindly by oneself to avoid adverse consequences.