Pyrazinamide is a kind of anti-tuberculosis drug, coughing after stopping pyrazinamide for tuberculosis may be due to poorer self-resistance, drug resistance, or it may be that the tuberculosis has relapsed again, and it is necessary to adjust the treatment program according to the cause of the disease, and then carry out the general treatment and medication after that. 1. Poor self-resistance: it has nothing to do with tuberculosis patients stopping medication, but may be due to poor self-resistance caused by coughing. After stopping the drug, you need to strengthen your own immunity to resist the invasion of various pathogenic bacteria, such as coughing is serious, you can follow the doctor’s prescription oral dextromethorphan to stop coughing. 2. Drug resistance: If you are resistant to pyrazinamide, you may cough again after stopping the drug, in which case you can change to other anti-tuberculosis drugs, such as streptomycin, isoniazid, rifampicin, carbamazepine, amikacin and so on. 3. Recurrence of tuberculosis: If tuberculosis is not fully recovered before stopping the medication, the disease may recur again. In this case, it is necessary to continue the medication until the tuberculosis bacillus is completely eliminated. Severe cases can be treated with glucocorticoid drugs, such as methylprednisolone. People who use pyrazinamide need to pay attention to, if allergic to the components of the drug, have liver and kidney insufficiency should be prohibited; people with liver function impairment need to use with caution. Long-term use of pyrazinamide may cause gastrointestinal discomfort, such as nausea, vomiting, loss of appetite, and some patients may experience dizziness, which is usually relieved after stopping the drug. If you need to take pyrazinamide must be under the guidance of a professional physician, during the period of unauthorized discontinuation or reduction of dosage.