If bile acids are high during pregnancy and cause cholestasis, there is no obvious harm to the pregnant woman, but it can cause things like a decrease in the synthesis of clotting factors and the possibility of postpartum bleeding. Bile acids can stimulate the uterus and release prostaglandins, which can induce contractions of the uterus. The effect on the fetus may cause premature birth. In pregnant women with cholestasis, the incidence of preterm labor can be as high as 30% or more. Due to the effect of bile acids, it can also cause some such pathological changes as a decrease in the volume of the intervillous space of the placenta and edema of the trophoblast cells. These pathological changes can cause impairment of oxygen and nutrient exchange between the fetus and the mother, resulting in intrauterine growth retardation, intrauterine hypoxia, and even intrauterine fetal death. Intrauterine death of the fetus often occurs suddenly and is unpredictable. Therefore, pregnant women with cholestasis should regularly monitor the fetal heartbeat and observe the fetal vital signs.