The initial symptoms of monkeypox virus infection in humans are generally not specific, and may include chills, fever, and malaise. Monkeypox virus is categorized as a genus of poxviruses in the family Poxviridae, and is one of the four genera of poxviruses that cause disease in humans. People are mainly infected through contact with exudates, blood, and other body fluids from infected animals, or by bites or scratches from infected animals. The incubation period after infection with monkeypox virus in humans is about 5 to 21 days, usually more 6 to 13 days. In the early stage of monkeypox, patients may have chills and fever, and most of the patients have a body temperature of 38.5℃ or above. In addition to chills and fever, patients may also have headache, drowsiness, fatigue, and myalgia, etc. In addition to the above symptoms, patients may also have other symptoms, such as fever and headache. In addition to the above symptoms, patients may also have enlarged lymph nodes in the neck, armpits, groin and other parts of the body. About one to three days after the onset of the disease, patients may appear specific skin rash, at this time patients can show typical clinical symptoms of monkeypox.