Lupus nephritis type IV is usually not completely curable. Lupus nephritis type IV is a pathological change of nephritis that manifests as diffuse proliferative lupus nephritis, and this type does not respond well to treatment. There may also be serious complications that may even lead to the death of the patient or the development of uremia, which requires renal replacement therapy. Depending on the severity of the disease, glucocorticoids (prednisone) and immunosuppressants (cyclophosphamide) may be used for induction therapy plus maintenance therapy, which can lead to symptomatic relief and slow down the rate of renal damage, but it is usually unable to cure completely. It is recommended that patients with lupus nephritis should go to regular hospitals in time and receive standardized treatment under the guidance of physicians, and the above medications should be used in accordance with the doctor’s instructions.