Vomiting blood in advanced uremia is usually a phenomenon caused by factors such as medications or toxins. Patients with advanced uremia may experience anorexia, nausea, vomiting, diarrhea, peptic ulcers and bleeding. Patients with advanced uremia are prone to hypertension, atherosclerosis, cardiomyopathy, pericarditis and cardiac insufficiency, which are usually treated with medications such as nifedipine, aspirin, and clopidogrel bisulfate, which may lead to gastrointestinal bleeding, which may result in vomiting of blood. Advanced uremia is also prone to toxin accumulation in the body, when the toxin accumulation to a certain amount can cause multi-system damage, mainly including anorexia, nausea, vomiting, diarrhea, peptic ulcers and bleeding, itching of the skin, anemia, convulsions and impaired consciousness, glucose tolerance abnormalities, pulmonary edema, lung bruising and ventricular block, cardiac insufficiency and other conditions, the patient is prone to vomit blood. Patients with advanced uremia can be treated by kidney transplantation or hemodialysis. It is also necessary to pay attention to a balanced diet and maintain a good state of mind, which can help alleviate the development of the disease. It is recommended that patients go to the hospital in time and actively cooperate with doctors to avoid delaying their condition.