Nucleic acid test refers to the new coronavirus nucleic acid test, negative fever is considered to be caused by upper respiratory tract infection, pneumonia, and requires medication. Secondly, the result may also be false negative, need to conduct nucleic acid test again, if the test result is positive, need to be isolated treatment. Patients with negative nucleic acid test results but fever symptoms can be considered to be caused by upper respiratory tract infection. The patient needs to identify the cause of the illness under the guidance of a doctor and treat the symptoms with antipyretic and analgesic medications, such as ibuprofen and acetaminophen. If the nucleic acid test result is negative, but the fever symptoms may also be due to sampling irregularities or viral infection in the incubation period caused by false-negative nucleic acid results. The patient needs to undergo another nucleic acid test, and if the test result is positive, the patient needs to be isolated and treated promptly. It is recommended that testers with fever should seek medical attention to identify the cause of the fever and select appropriate treatment measures, taking into account the epidemiologic evidence of the patient’s condition.