Headache in the middle of the night is common in the following four possibilities: 1, there may be a migraine attack, this disease often has a family history and history of recurrent episodes, severe accompanied by nausea, vomiting, photophobia, photophobia, the common parts of the headache is bilateral temples and the back of the neck, is often throbbing throbbing pain lasts a few hours can be relieved, and often affects the daily life and work. 2, there may be a cluster headache, the headache attack is more Intense, accompanied by ipsilateral eye redness, tearing, ipsilateral nasal congestion, often seen on one side of the orbital region and forehead pain, characterized by often at the same time every day seizures. 3, there may be tension-type headache, often seen in insomnia and anxiety patients with the degree of pain is not heavy, there is a feeling of tightening the spell like, the pain is commonly found in the forehead for a week. The degree of pain is not heavy often does not affect the work and life. 4, the probability of cerebrovascular disease is not large, common is subarachnoid hemorrhage or arterial entrapment, if long-term recurrent headaches need to pay attention to the hospital neurology to rule out cerebrovascular disease.