The upset stomach, nausea and vomiting in the middle of the night are considered to be related to the food consumed. For example, consuming unclean food, or consuming food that is not fried can lead to the above symptoms. It can also be caused by overeating cold, oily and spicy foods. If acid reflux and heartburn are obvious, you can take oral proton pump inhibitors, such as omeprazole enteric-coated capsules, lansoprazole, rabeprazole and esomeprazole, etc.; gastric mucous membrane protectants, such as bismuth compound bismuth aluminate granules, bismuth in pectin, aluminum phosphate gel, aluminum thioglycollate, etc.; applying gastrofibric acid tablets orally in order to, to stop nausea, vomiting treatment. If bloating is obvious, domperidone and mosapride can be added to promote gastrointestinal motility. If the patient is combined with loss of appetite, can be added with gastrointestinal tablets, pancreatic enzyme enteric coated tablets and other digestive treatment. If there is no improvement after oral drug treatment, it is recommended to improve gastroscopy or abdominal ultrasound and other related examinations, in order to clarify the diagnosis and guide the next step of treatment.