Hydronephrosis is often caused by urinary tract obstruction, so the first principle of treatment is to release the obstruction, and the drug treatment includes anti-infective treatment (such as levofloxacin, cefixime), lithotripsy (such as sodium citrate, allopurinol), and so on, and surgery is feasible when necessary. Because of individual differences, it is necessary to choose the appropriate drugs for treatment under the guidance of doctors. 1. Anti-infection treatment: hydronephrosis will lead to urine stagnation and poor drainage, which will easily cause bacterial infection, and antibiotics can be used for anti-infection treatment. Commonly used antibiotics are levofloxacin, cefixime, cefuroxime and so on, before using the drugs need to complete the urine culture test, according to the drug sensitivity test to choose sensitive antibiotics. 2. Lithotripsy: If the hydronephrosis is caused by stones in the urinary system, it is necessary to correct the cause of the disease and carry out lithotripsy first. By changing the pH value of urine to increase the solubility of stones. Drugs such as sodium hydrogen potassium citrate and allopurinol can be used to treat uric acid stones, and thiopronin and acetylcysteine can be used to treat cystine stones. Extracorporeal shock wave lithotripsy, etc. is feasible when necessary. All of the above drugs should be standardized under the guidance of a physician, and should not be used without authorization, so as not to aggravate the condition. Patients with hydronephrosis are advised to consult regular hospitals for standardized treatment under the guidance of physicians.