Jaundice is the increase of bilirubin in liver function index, more than the normal value will appear urine yellow, more than double the normal value will appear eye yellow, more than 2 times will appear skin yellow stain. Jaundice is an important indicator of liver function, and a common saying of hepatologists is that high aminotransferases are not scary, but high jaundice is. Once jaundice occurs, it means that the patient’s liver function is seriously impaired. If the bilirubin is more than 10 times of the normal value, and the daily increase is more than one times of the normal value, it is necessary to consider whether the patient is in liver failure. Some patients have bilirubin increase with itching, which is due to cholestasis and bile salt irritation of peripheral nerves.