There is a certain risk of doing painless gastroscopy in older age, especially the presence of underlying diseases, such as cardiovascular disease, hypertension and other risks will increase. Painless gastroscopy is the application of anesthesia drugs before doing the examination, after the anesthesia drugs take effect, the examination is done in the state of sleep, which is conducive to the smooth progress of the examination, but older to do painless gastroscopy has certain risks, especially the presence of cardiovascular disease, hypertension, respiratory diseases, such as hypoxemia, respiratory depression and so on, the risk will be increased accordingly. Therefore, it is necessary to rule out contraindications before doing painless gastroscopy, make a comprehensive assessment based on the patient’s specific situation, and decide whether it is suitable for painless gastroscopy under the guidance of the doctor.