The spread of cancer does not necessarily mean that the pain is no longer there, it is possible that the pain is more severe, and what was originally localized pain may spread to include pain in all parts of the body, which is a sign of the progression of the disease. The spread of cancer also means that treatment is more difficult, and pain treatment can be more difficult. Those with more severe pain can apply strong painkillers, such as oxycodone or strong opioids like morphine, which can usually stop the pain. If there is extensive spread and the pain is metastasized throughout the body, the amount of pain medication may need to be added, which means that opioid pain relief can be uncapped. For the extensive spread of cancer, in addition to the application of pain medication, you can also apply anti-tumor treatment to control the development of the disease, but also can stop the pain, such as radiotherapy, etc., if the tumor can be shrunk, but also can stop the pain.