Intestinal mesenchymal tumors are a special group of the most common mesenchymal tumors of the gastrointestinal tract characterized by positive CD117 protein expression. Whether intestinal mesenchymal tumors are serious or not is closely related to the size of the tumors, pathologic nuclear schizophrenic images, and whether the tumors are ruptured or hemorrhagic, and other factors. If the intestinal tumor is relatively small, without any clinical symptoms, usually less than 2cm within the mainly benign, its malignant risk degree is very low, the tumor cell proliferation index is also low. If the tumor continues to proliferate and enlarge, rupture, bleeding, more pathological nuclear schizophrenic images, tumor >5cm, or even more than 10cm, the risk of malignancy is higher and the condition is more serious. It is recommended that patients should closely follow up the diagnosis, regular review, and seek medical treatment in time if there are clinical symptoms, and if necessary, surgical resection or targeted drug therapy. In general, the prognosis of intestinal mesenchymal tumors is significantly worse than that of gastric mesenchymal tumors, and the related mortality rate is 40%-50% higher than that of gastric mesenchymal tumors. Therefore, patients must follow up closely and review regularly for early detection and treatment, which usually has a better effect.