Severe osteoporosis can be treated, but it is difficult to cure completely. If osteoporosis is accompanied by some pathological fractures such as fragility fractures or more serious complications of osteoporosis, it is called severe osteoporosis. In this case, patients can be treated by drugs, physical and surgical methods, but it is difficult to return to the normal level of bone mass. 1. Drug treatment (1) Estrogen: commonly used drugs include estradiol, ethinyl estradiol, compound estrogen, nil estradiol and other drugs. (2) Calcitonin: e.g. E-calcitonin, salmon calcitonin injection, etc. (3) Vitamin D: such as alfacalcitol, etc. (4) Calcium preparations: inorganic calcium such as calcium chloride, calcium carbonate, organic calcium such as calcium gluconate, calcium lactate and so on. (5) Bisphosphonates: such as disodium chloromethyl bisphosphate, sodium hydroxyethyl diphosphate and so on. (2) Physical therapy: including light therapy, high-frequency electrotherapy, exercise therapy and so on. 3. Surgical treatment: patients with fractures can be treated with minimally invasive surgery for cemented vertebroplasty. If you are diagnosed with severe osteoporosis, you should go to the hospital in time and take regular treatment under the guidance of the doctor to avoid serious complications. Blind self-medication should be avoided.