Pearly rash on the penis, i.e., pearly penile papules, is considered to be caused by physiological developmental variants or local irritation. The main symptom of the patient is pearly papules at the coronal groove of the penis, which can be treated with medication, surgery, and other treatments. Patients with pearly penile papules may be due to physiological developmental variants in the patient, or may be due to localized irritation such as prolonged foreskin and poor hygiene. Patients will have pearly and translucent papules on the coronal edge of the penis or in the coronal sulcus, and most patients have no conscious symptoms. If the penis is simple pearl rash, no special treatment, most can be self-cured; if combined with the infection, can follow the doctor’s instructions to use cleaner lotion and other topical lotions to stop itching and anti-inflammatory, can also use mupirocin ointment, erythromycin ointment and other antibiotic ointment. If necessary, you can take circumcision for surgical treatment, and some patients can take cryotherapy, high-frequency electrosurgical therapy, laser therapy and so on. Patients with symptoms of pearly rash on the penis should seek medical attention, identify the cause of the disease, and follow the doctor’s instructions for treatment.