Recently a neonate with complete transposition of the great arteries (TGA) was successfully treated in our clinic. The child came 14 days after birth with severe hypoxemia (saturation consistently below 30%) and was immediately given prostaglandin E1 continuous pumping when he entered the monitoring room. After regular medical treatment the child’s general condition did not improve and the lactate was further increased. After the surgery, the aortic cannula and the right atrial cannula were connected directly to the ECMO tube, and the patient was transferred directly from extracorporeal circulation to ECMO assisted by delayed chest closure back to the monitoring room. The lactate dropped to normal after 10 hours of assistance, and when the assistance reached 4 days, the circulation was stable and the respiratory index was stable, the ECMO was withdrawn, the chest was closed, and the tracheal intubation was removed after 1 day. The child is currently in stable condition.