Acromegaly, medically known as amyotrophic lateral sclerosis, is a chronic progressive degenerative disease that involves upper motor neurons, including the brain, brainstem, and spinal cord, and affects lower motor neurons, including the cranial nerve nuclei, anterior horn cells of the spinal cord, and the muscles of the trunk, extremities, and head and face they innervate. The cause of the disease is still unclear and may be genetically and genetically related, or it may be related to environmental factors, such as heavy metal poisoning. The clinical manifestation is often a mixed paralysis with combined damage to upper and lower motor neurons, which may include tongue muscle atrophy, tongue muscle fibrillation, strong crying and laughing, and emotional instability. The upper extremities mostly show distal dominant muscle atrophy, with the large and small interosseous muscles being obvious, along with muscle bundle tremors, but normal sensation. Spastic paralysis, increased muscle tone, hyperactive tendon reflexes, and positive bilateral pathological reflexes are seen in both lower extremities, and dyspnea is seen when respiratory muscles are involved. Early symptoms are not prominent and may only manifest as weakness, easy fatigue or flesh throbbing, but these symptoms will gradually worsen.