Glomerulosclerosis 80% indicates more serious kidney damage, but the survival time can be prolonged by renal replacement therapy, and its survival time cannot be generalized. Glomerulosclerosis 80% indicates that the glomerular filtration rate is severely decreased, entering the stage of chronic renal failure, and eventually progressing to end-stage renal disease, which requires renal replacement therapy, such as hemodialysis, peritoneal dialysis, etc. Regular dialysis treatment, and follow the doctor’s instructions for complications, the 10-year survival rate is about 45%, but the specific situation varies from person to person, and cannot be generalized. At present, the best renal replacement therapy is renal transplantation. If a successful renal transplantation can be performed, normal renal function may be restored, thus not affecting the survival time. However, long-term regular oral immunosuppressant anti-rejection therapy, such as tacrolimus, is needed. It is recommended that patients with glomerular sclerosis should go to the hospital in time and follow the doctor’s instructions for symptomatic treatment to avoid delay and aggravation of the condition.