Hepatitis B generally refers to chronic hepatitis B. When chronic hepatitis B has previously resolved spontaneously, the alpha-fetoprotein is usually not high. If alpha-fetoprotein is abnormally high, it is considered to be caused by liver cancer and other diseases, and the cause should be identified in time. Alpha-fetoprotein is a kind of glycoprotein, which is mainly composed of fetal stem cells and yolk sac. It is closely related to the occurrence of hepatocellular carcinoma and many kinds of tumors, and can be used as a positive indicator for many kinds of tumors in clinic. The normal value of normal serum alpha-fetoprotein is less than 25ng/ml. if the patient has abnormal elevation of alpha-fetoprotein, it is considered to be caused by liver cancer, hepatoblastoma, ovarian tumor and other diseases. Chronic hepatitis B is caused by hepatitis B virus infection, and its onset and progression are related to a variety of factors such as the virus, the infected person, and the environment. The disease is contagious and can be transmitted through blood and body fluids. Patients with chronic hepatitis B, if the condition is not well controlled, the virus continues to replicate and cause damage to the liver, the liver will develop fibrous lesions, and repeatedly, there is a possibility of developing cirrhosis, and the risk of liver cancer is significantly higher than that of healthy people. If patients with chronic hepatitis B recover from the disease, the liver will not be further damaged by the virus and develop into cirrhosis, and the possibility of liver cancer is not much different from that of healthy people, and the elevation of alpha-fetoprotein will not occur in general. If the value of alpha-fetoprotein rises abnormally after hepatitis B is cured, it should be taken seriously, and it is recommended to go to the regular hospital in time to find out the cause of the disease.