Creatinine 200μmol/L can be caused by physiological reasons such as high muscle content or eating more meat and exercising more, and pathological reasons such as acute kidney injury and chronic renal insufficiency. 1. Physiological reasons: some patients’ creatinine increase may be caused by eating a lot of high protein food, having high muscle content, or exercising more. 2. Pathologic causes: (1) Acute kidney injury: pre-renal causes such as insufficient effective blood volume and reduced cardiac output, renal causes such as renal ischemia and nephrotoxic substances leading to renal tubular epithelial cell injury, etc., and post-renal causes such as prostate hypertrophy and tumors, etc., may increase creatinine. (2) Chronic renal insufficiency: primary renal diseases such as glomerulonephritis, tubulointerstitial disease, renal vascular disease, etc., and secondary renal diseases such as diabetes-induced nephropathy, hypertension-induced nephropathy, etc., as well as hereditary nephritis, polycystic kidney, etc., can lead to elevated creatinine. If patients find that the creatinine is elevated, it is recommended to go to regular hospitals in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy under the guidance of the doctor.