Itchy skin is a self-conscious symptom that occurs when nerve endings in the skin are stimulated by internal or external factors to produce nerve impulses that are transmitted to the cerebral cortex. Pain results from strong stimulation. At first there is no special manifestation on the skin, but due to scratching causing skin damage, scratches, erythema, blood scabs appear on the skin, and over time the skin thickens and forms mossy, turning into chronic dermatitis. Some primary skin diseases skin inflammatory changes can then stimulate the nerve endings to cause itchy skin. How to treat itchy skin? First, the first thing to look for the cause: itching causes many, very complex, requires patience to exclude the cause. Simply put, it can be divided into: internal causes: internal changes in the body caused by itchy skin. Neuropsychiatric factors, conditioned reflexes, somatic diseases (such as liver and gallbladder disease, uremia, diabetes, arteriosclerosis, neurosis, etc.), metabolic abnormalities, endocrine disorders, tumor metabolites, drugs, food allergies, internal lesions, etc. External causes: external body contact items, including changes in temperature, substances contained in the air, harmful gases, particulates, bacteria, viruses, insects, animal fur, body contact clothing, bedding, toiletries, cosmetics, various parts of plants. The itch can be caused by the items that you may come into contact with during work and labor, as well as by poor hygiene habits. To find out the cause you have to remove the cause to cure the itch. There is itchy skin to try to investigate the internal and external causes. Second, symptomatic treatment – stop itching: remove the cause of itching but the skin scratching can not immediately disappear. It needs to be treated symptomatically according to the itch – to stop the itch and relieve the pain. 1, local treatment of itchy skin: (1) topical drugs for itchy skin: containing menthol, camphor, phenol, ice chips, benzocaine and other anti-itch agents, such as phenol glutamate lotion, compound menthol lotion, compound camphor ointment, 5% doxepin hydrochloride cream, dacronin ointment, glucocorticoid ointment or cream; each hospital has its own preparation for anti-itch. (2) Local closure therapy for pruritus: subcutaneous infiltration injection with benadryl 25mg plus appropriate amount of procaine at the lesion, once every other day; also use de-inflammatory pine or dexamethasone plus appropriate amount of procaine at the lesion for subcutaneous closure, 1-2 times a week. (3) physical therapy of pruritus: cold compresses, systemic pruritus feasible ultraviolet radiation, subcutaneous oxygen infusion, starch bath, bran bath or mineral bath, etc.; limited recalcitrant pruritus by multiple treatment is ineffective, can consider isotope or superficial X-ray treatment. 2, systemic treatment of pruritus: (1) antihistamines: the first-line drugs, a variety of H1 receptor antagonists can be used: such as chlorpheniramine fumarate, cyproheptadine hydrochloride, benadryl, Antares, cetirizine hydrochloride, etc. H2 receptor antagonists can also be used in combination; calcium, vitamin C, etc. can enhance the efficacy of antihistamines. (2) Antidepressants, sedatives, sleeping agents: due to neuropsychiatric itching of the skin or sleep disorders caused by itching optional such drugs. (3) Calcium (calcium gluconate, calcium chloride), sodium thiosulfate injection, etc. (4) Sex hormones: commonly used in elderly patients, male patients with testosterone propionate 25mg/d twice a week intramuscularly, or methyltestosterone 5mg/d orally; female patients can be used with estradiol 1mg/d in 2 oral doses, or progesterone 10mg/d intramuscularly. Reproductive system tumors or liver and kidney insufficiency should be avoided just or cautiously used. (5) Other: naloxone injection is effective in patients with cholestasis, and amitriptyline is available when ineffective. Third, the treatment of the original cause of pruritus – scratchy skin disease: need to cooperate with doctors to find the cause of active treatment.