Pruritus is very common in diabetic patients, with a statistical incidence of 7%-43%. It can manifest clinically as generalized pruritus or localized pruritus in the anus, female genitalia, and scrotum. Diabetes combined with pruritus, generalized and limited pruritus account for about half of the cases, and there are few people who are clinically diagnosed with diabetes due to persistent pruritus. Although generally speaking, the prognosis is good, but its pain is abnormal, diabetes-induced pruritus of the skin more, aggravated at night, can directly affect the patient’s sleep, and even seriously affect the patient’s life and work, and become an important factor in the difficulty of controlling blood sugar and blood pressure in diabetic patients. Diabetes mellitus combined with pruritus of the skin is a skin disease related to achalasia in Chinese medicine. Patients who scratch their skin due to itchiness and show bloody scars are called “blood and wind sores”. Itchy skin, itchy vulva, called “Yin itch”, itchy around the anus, called “anal itch”. Itchy skin even causes blood glucose fluctuations, and local skin may be dry, flaky, cracked, and have a change in skin color, and scratch marks after scratching. It is very common in diabetic patients, especially in elderly patients and female patients, and in women it is more common to see wet itchy skin, sometimes accompanied by leucorrhea, smelly, itchy skin, scratching the water, etc.. The total can be said to be very painful, seriously affecting the quality of life of diabetic patients. Modern medical understanding of the causes and pathogenesis of diabetes combined with pruritus: Modern medicine believes that there are many factors that cause itchy skin, both internal and external. Diabetic patients itch due to increased glucose content in the skin, which stimulates itchy skin, or due to chronic dehydration of the skin for a long time, reduced sweating and excessive dryness of the skin. In addition neurological reflexes, uremia, etc. can also cause pruritus. Local itching is mostly caused by urinary sugar stimulation and fungal infection. Patients with pruritus are extremely sensitive to external stimuli, such as hot and cold changes, clothing friction, contact with chemical fiber fur fabrics, drinking and eating spicy food can trigger pruritus. Diabetes can cause different degrees of atrophy and degeneration of nerve fibers, swelling of myelin sheaths, separation of laminae and demyelination, which can lead to abnormal nerve function and disturbance of neurotransmitter release by nerve fibers, such as slow response, abnormal transmitter release, uncontrolled transmitter release and blocked transmitter release, which can lead to abnormal skin reactions such as dry skin, itching and rash. pruritus, rash, etc. For patients with diabetic itchy skin, basic treatment includes the following: 1. Eat a light diet, avoid alcohol and spicy stimulating foods. 2. 2, do not scratch, scratching can make itching spread. If the body local itching attacks, you can apply anti-itch drugs on the itchy area, or gently pat the itchy area, do not scratch excessively, in order to get a momentary pleasure. 3, avoid hot water scalding and soapy water stimulation, appropriate control of the number of baths, avoid using too strong alkaline soap, or too much friction, bath water temperature is maintained at 37-40 ℃. After the bath, you can apply emollient products. Pay attention to wearing cotton fabrics inside the body, avoid chemical fiber, fur stimulation. 4, pay attention to keep the vulva and anus clean and dry. 5, regular rest and relaxation, to maintain a comfortable mood, rich spare time, and actively participate in sports and recreational activities to distract attention. Modern medical treatment methods include: 1. actively control blood sugar actively apply oral hypoglycemic drugs or insulin injection therapy to control blood sugar in the normal range. 2, symptomatic treatment of itching local, can be topical anti-itch agents, such as compound peppermint tincture, menthol glycerin lotion, camphor tincture, anti-itch cream, etc.. Systemic itching can be taken internally with antihistamines such as paracetamol and benadryl. Combined with candida infection caused by vulvar itching, can be used 2%-4% sodium bicarbonate solution rinse vulva, local use of mycobacterium ointment, dacrynic cream, etc.. 3, improve microcirculation and neurotrophic agents for the combination of more severe and microvascular lesions of pruritus patients, mostly difficult to treat, should be appropriate to improve the microcirculatory disorders and nerve nutrition drugs.