Muscle spasm and hypertonia are common complications after central nervous system injury, which seriously affect the functional activities and quality of life of patients. The common muscle spasms and hypertonia after stroke are flexor elbow muscles, forearm rotator anterioris roundus (sometimes including rotator anterioris), flexor carpi radialis, flexor digitorum longus, and thumb flexor muscles in the upper extremity, and triceps and posterior tibialis muscles in the lower extremity. The common muscle spasms and increased muscle tone after spinal cord injury are the adductor muscles, s cord muscles, triceps minor, and posterior tibial muscles of the lower extremities. In addition, there are also some idiopathic muscle tone abnormalities, such as facial spasm and spastic slant neck. Clinical management includes physical therapy (retraction training, vibration therapy, heat therapy), oral medications (baclofen, tizanidine, Myna, Valium, etc.), and nerve blocks (botulinum toxin, anhydrous alcohol). For those whose muscle tone reaches grade 2 or higher in modified Ashworth, and who have poor results in physical therapy and medication, nerve blocks are considered to reduce muscle tone and relieve spasticity faster, to create conditions for rehabilitation training, to improve functional activities, and to increase the ability of daily living activities. EMG and nerve conduction technology can accurately locate the target muscles and nerves to achieve precise positioning of nerve blocks and obtain better treatment results. We have completed hundreds of cases of botulinum toxin injection for upper and lower extremities, oblique neck and facial muscle spasm, and dozens of cases of anhydrous alcohol block for closed nerve, sciatic nerve and tibial nerve, with good clinical results.