In general, the presence of HP+ on gastroscopy is less serious and is defined as a positive rapid urease test on gastroscopic mucosal tissue biopsy, suggesting the presence of Helicobacter pylori infection, but not serious. Helicobacter pylori is a spiral-shaped, slightly anaerobic bacterium with very demanding growth conditions.It was first successfully isolated in 1983 from gastric mucosal biopsy tissue of patients with chronic active gastritis and is the only microbial species known to be able to be generated in the human stomach.In 2017, the International Agency for Research on Cancer (IARC) of the World Health Organization placed Helicobacter pylori on the list of class I carcinogens. H. pylori can cause gastritis, peptic ulcers (including gastric and duodenal ulcers), lymphoproliferative gastric lymphoma, and gastric cancer. It can cause fullness, discomfort or pain in the upper abdomen after meals, often accompanied by belching, nausea, vomiting, acid reflux, heartburn, loss of appetite, and other symptoms, as well as symptoms of upper gastrointestinal bleeding such as vomiting blood and blood in the stool. Gastroscopy finding HP+ generally suggests H. pylori infection, but it is not serious. It is recommended to seek timely medical treatment and give quadruple therapy for eradication under doctor’s guidance to avoid delay.