Epididymitis nodules, indicating the presence of localized inflammatory nodules, the main treatment methods include drug treatment, surgical treatment. 1. Drug treatment: due to the presence of infection, antibacterial drugs should be used for treatment, such as ceftriaxone, levofloxacin and so on. When there are obvious pain symptoms, you can also use lidocaine for spermatic cord closure treatment, which can relieve the pain symptoms. 2. Surgical treatment: long time existence of nodules, recurrent infections, the infection will be controlled, you can consider surgical treatment, through surgery to remove the nodules, such as epididymal nodule excision, etc., in the postoperative care, maintain lower body hygiene, light diet, do not drink alcohol and smoking. To summarize, in the process of treatment, we must follow the doctor’s instructions, safe and reasonable use of medication, do not indiscriminate use of medication.