Patients with symptoms of breast hyperplasia can be vaccinated with the new crown booster shot without clear contraindications. When receiving the new crown booster shot, it is necessary to clarify the relevant contraindications to avoid damage to the organism, but breast hyperplasia does not belong to the contraindications, so the patient can usually receive the vaccine normally, and it will not cause significant impact on the condition. The contraindications for the new crown booster shot are usually severe allergic reactions, allergy to any component of the new crown vaccine, and uncontrolled epilepsy, all of which are contraindicated. Other serious neurological conditions such as Guillain-Barre syndrome and transverse myelitis are also contraindicated. Patients with breast enlargement are advised to regulate pain during menstruation under the guidance of a doctor, reduce psychological pressure, and avoid discomfort during booster injections.