Nighttime gallbladder pain may be related to cholelithiasis, cholecystitis, biliary ascariasis, etc., and need to be treated with medication or surgery for the cause, and should not be treated blindly with small tricks. 1. For those caused by cholelithiasis, surgical treatment is the mainstay, and cholecystectomy should be considered first. 2. For cholecystitis caused by, can follow the doctor’s instructions oral atropine and other antispasmodic painkillers, ursodeoxycholic acid tablets and other choleretic drugs; according to the specific circumstances of the choice of cholecystectomy, cholecystostomy and so on. 3. For biliary ascariasis caused by biliary roundworm disease, can be prescribed oral anthelmintic such as albendazole, scopolamine and other antispasmodic analgesics, metronidazole and other antibacterial drugs to prevent infection; if drug treatment is ineffective, feasible choledochotomy, cholecystectomy, and other choledocholithiasis. It is recommended that people with nocturnal gallbladder pain go to the hospital in a timely manner, to clarify the cause of the disease, standardized treatment under the guidance of the doctor, and not blindly apply their own tricks, so as not to delay the condition. The use of drugs need to follow the doctor’s instructions.