Penile pearly papules, or penile pearly papulosis, may be a physiological developmental variant, generally no uncomfortable symptoms do not require special treatment. If symptoms such as itching occur, medication can be used. Pearly translucent papules can be seen in the coronal groove, usually the size of a pinhead to a grain of rice along the coronal groove. When the patient is infected, itching and other symptoms can occur, need to use drugs to relieve the symptoms. You can choose to clean the affected area, and at the same time, apply mupirocin ointment, and when the lesions are serious, you can apply fluorouracil ointment and so on. If the patient feels that it affects the aesthetics, you can also follow the doctor’s advice to choose liquid nitrogen cryotherapy, electrocautery therapy and laser therapy. The above drugs are for reference only, the specific use of drugs need to follow the doctor’s instructions, the appearance of penile perlage if accompanied by discomfort, it is recommended to go to the regular hospital.