The main causes of thigh muscle soreness from sitting to standing are poor blood circulation, nerve entrapment and poor venous disease, etc. Treatment mainly includes general treatment and medication. 1. Poor blood circulation: Suddenly standing up after a long period of sitting will cause thigh soreness due to a sudden and temporary lack of blood supply. First of all, avoid muscle fatigue in a posture for a long time; secondly, you can choose hot compresses, massage, microwave and other physical therapy to accelerate blood circulation in the lower limbs and promote acidic metabolites to be discharged. 2. Nerve compression: patients with lumbar disc herniation or cervical spondylosis, because of the spinal cord nerves and sciatic nerves are compressed and stimulated, in the sitting position to standing will appear thigh pain. Oral medications are an option. Commonly used oral medications include non-steroidal anti-inflammatory drugs such as diclofenac, ibuprofen, etc.; circulatory improvement drugs such as Diosmin tablets. 3. Venous diseases: Diseases such as varicose veins and venous thrombosis in the lower limbs can cause pain in the thighs from sitting to standing due to the obstruction of venous blood return. The main treatment is surgery to dislodge the diseased vein and remove the thrombus. If symptoms are not relieved, or if they are accompanied by other symptoms, it is important to go to the hospital in time to have the cause clarified and then give targeted treatment.