Inguinal metastasis of melanoma is necessary to be treated, and timely treatment is of great help to the disease control and prolongs the survival time, which needs to be combined with the patient’s physical condition to carry out standardized treatment. The most common site of melanoma metastasis is inguinal lymph nodes, some of them are single metastasis, which can be resected by radical surgery; for patients who cannot be resected by surgery, they need to be controlled by radiotherapy, targeted or immunotherapy as early as possible, so as to slow down the progression of the disease as much as possible and prolong the survival time. Melanoma is a tumor with high malignancy, if it is not controlled in time, the disease will develop rapidly and multiple metastases will easily occur. Patients with inguinal lymph node metastasis need to seek medical treatment in time and under the guidance of clinicians for standardized treatment.