Gastric cancer is a common malignant tumor of digestive system, and many patients with advanced gastric cancer will have clinical manifestations of pain. For advanced gastric cancer pain, according to the nature and degree of pain, pain relief drugs are given according to a ladder, and at present, pain relief drugs are divided into three ladder drugs. The first ladder drugs are mainly anti-inflammatory and analgesic drugs, including ibuprofen, Xilabao, anti-inflammatory pain, acetaminophen, etc. The second step of medication as long as the weak opioid drugs, including tramadol, aminophenol dihydrocodeine, aminophenol oxycodone, etc.. The third-order drugs are mainly strong opioids, including morphine immediate-release tablets, morphine extended-release tablets, oxycodone extended-release tablets, fentanyl transdermal patches, and buprenorphine transdermal patches, which are applied when oral medications are not available.