Yellow vaginal discharge in 80 years old people can be considered as senile vaginitis (atrophic vaginitis) or gynecological tumors such as cervical cancer, endometrial cancer, etc. It can be treated by topical plus oral estrogen, antibiotics and other medicines, or treated by surgery and radiotherapy. If 80-year-old people have yellow vaginal discharge, accompanied by itching, odor and other symptoms, the main consideration is geriatric vaginitis (atrophic vaginitis) or gynecological tumor manifestations, after the routine leukorrhea, cervical secretion laboratory and exfoliative cytology examination and diagnosis can be clearly diagnosed. If the elderly are suffering from senile vaginitis, they can apply estriol ointment locally, take tibolone internally to supplement estrogen, or choose estrogen-progestin combination therapy. In addition, anti-infection treatment can also be carried out by using compound metronidazole vaginal suppositories placed deep in the vagina. In case of cervical cancer and endometrial cancer, early surgery should be performed to remove them as clean as possible, and then radiotherapy and targeted drugs should be performed to inhibit tumor progression, avoid tumor metastasis, prolong patients’ survival and improve patients’ quality of life. Therefore, when 80-year-old people have yellow discharge, they must go to the gynecology department of local hospital as soon as possible to find out the cause of the disease and actively carry out medication, and the use of medication should be carried out under the guidance of doctors.