Diffuse intravascular coagulation is a very aggressive disease, and whether or not it can be cured is related to the patient’s primary underlying disease. For example, a patient with an oncology that presents with disseminated intravascular coagulation usually has a very high mortality rate, but if it is caused by infection or trauma, or if the mother has a difficult labor, as long as it is handled appropriately and in a timely manner, the patient’s chances of salvage are often much better. Disseminated intravascular coagulation (DIC) is not a stand-alone disease, but is a clinicopathologic syndrome that is the ultimate common pathway of coagulation dysfunction in the progression of many diseases. As a result of diffuse activation of intravascular coagulation mechanisms, it promotes extensive fibrin deposition in small blood vessels, leading to tissue and organ damage; on the other hand, it causes systemic bleeding tendency due to the depletion of coagulation factors. Rapid and effective treatment of the primary disease is of paramount importance, including antibiotic and anti-infective therapy, anticancer therapy, surgical and pharmacologic treatment of trauma, and stillbirth removal. Since most patients with DIC are critically ill, appropriate supportive therapy is necessary, including fluid administration, pressure elevation, dialysis, and ventilator use. Patients are advised to actively treat the primary disease to prevent the occurrence of DIC.