Progesterone can regulate the endometrium of women, but it has its own indications, as long as it is the right medication will have a role. In clinical practice, progesterone to regulate the endometrium is mainly applicable to the following three situations: First, patients with abnormal proliferation of the endometrium, complex hyperplasia or carcinoma in situ. If the patient can’t do surgery for some reasons, the patient can choose to use progesterone for treatment, and progesterone needs to be used for a long time when taken orally. If the patient does not want to take progestin orally every day, he/she can choose to place Mannuelle ring in the uterine cavity, which can release progestin locally, and the side effects on the whole body are relatively small. Secondly, when patients have endometrial polyps, progesterone can be used to counteract estrogen, inhibit the growth of the endometrium, and inhibit the recurrence of endometrial polyps. Third, when the patient has luteal insufficiency, resulting in abnormal stripping of the endometrium and irregular vaginal bleeding, progesterone can be used to regulate the patient to start taking after ovulation, for about 14 days, after stopping the drug, the patient’s menstruation will come on time and clean up on time.