Long-lasting and no side effects of the drug is not currently available, any drug oral or topical medicine, are more or less some side effects. Commonly used oral delay drug is generally Dapoxetine, some people produce side effects are headache or dizziness, some people are nausea symptoms. Topical local anesthetics are generally used to reduce the sensitive nerves on the surface of the glans and penis through local anesthesia thus achieving a lasting effect. Possible side effects are that they may cause paralysis of the penis, inability to get an erection, etc. Long-lasting drugs can improve male libido, if suffering from premature ejaculation and other symptoms, you can use long-lasting drugs to improve the quality of sexual life, but do not recommend long-term use, to avoid long-term use of the body to bring side effects affecting the health of the body. It is recommended that you exercise more and eat a balanced diet in your daily life.