Low differentiated pancreatic cancer suggests that pancreatic tumors have low differentiation and high malignancy, and patients often have poorer prognosis. Pancreatic cancer adenocarcinoma mostly occurs in the head of pancreas, presses the bile duct and invades the surrounding tissues, and it is very easy to have early metastasis due to the abundance of blood vessels and lymphatic vessels around the pancreas, and most of the tumors have already metastasized when the diagnosis is confirmed. Abdominal pain is the first symptom of pancreatic cancer. Due to the obstruction of bile duct, dyspepsia, gradually aggravating jaundice, emaciation and malignant state are often found in the late stage of the disease. Pancreatic cancer has no typical symptoms in early stage, so it is difficult to diagnose. When typical signs appear, the disease has already developed to advanced stage and the opportunity of surgical treatment is lost. Pancreaticoduodenectomy is feasible for patients with small lesions that can still be operated, but the prognosis is still poor. According to some studies, the 5-year survival rate of pancreatic cancer patients after surgery is less than 8%, and the survival period of untreated pancreatic cancer patients may not exceed 4 months. Lowly differentiated cancers are more malignant and often have a worse prognosis. Once diagnosed with pancreatic cancer, patients should actively cooperate with the treatment to control the progression of the disease and prolong the prognosis as much as possible.