Acute cholecystitis combined with pregnancy can occur in all stages of pregnancy, and in general, the specific measures for treatment are as follows. Non-surgical treatment 1. Diet control: Usually, patients with severe disease should fast; in mild patients with symptom onset, fatty diet should be prohibited, and if in remission, a high sugar, high protein, low cholesterol diet can be given. Appropriate fluid supplementation, vitamin supplementation, correction of water and electrolyte imbalance. 2, symptomatic treatment: when severe pain occurs and is unbearable, symptomatic treatment should be given, such as atropine, dulcolax intramuscular or subcutaneous injection, sublingual nitroglycerin tablets, etc.. In the remission period, appropriate cholagogic drugs can be taken, such as oral ursodeoxycholic acid or bile enzyme, etc. 3.Anti-infection treatment: Usually, broad-spectrum antibiotics cephalosporins have 4-12 times higher concentration in the bile than in the blood and have no adverse effect on the fetus, and will be preferred. Doctors will take specific anti-infective treatment according to the condition. Surgical treatment If the effect of non-surgical treatment is not good and the condition worsens, or if the gallbladder has accumulated pus, peribiliary abscess, and the gallbladder is perforated to form acute diffuse peritonitis, surgery should be performed as soon as possible. In critical cases, the mother’s health should be considered first. In early and middle pregnancy, laparoscopic removal of the gallbladder is safer for the mother and child and has no obvious adverse effects on pregnancy; 2. In late pregnancy, surgery should be simple, including cholecystostomy and drainage, cholecystectomy or local drainage of pus from the lesion, etc. In cases with obstructive duct stones, incision and drainage should be performed. After the operation, pay attention to the presence of contractions, and give timely progesterone or magnesium sulfate and other fetal preservation treatment. Warm tip: The doctor will adjust the medication and treatment according to the patient’s specific condition, and the patient should actively cooperate with the doctor. If female patients have gallbladder stones, please visit the general surgery department before pregnancy to eliminate hidden problems in time so as not to affect disease treatment and normal pregnancy.