Uremia is the final outcome of the continuous progression of various chronic kidney diseases. Uremia caused by hereditary kidney diseases such as polycystic kidney and Fabry disease is hereditary; uremia caused by other diseases such as primary glomerular disease, diabetic nephropathy and lupus nephritis may not be hereditary. Patients with uremia have decreased renal metabolism and excretion, and are prone to water, electrolyte and acid-base balance disorders, potassium, phosphorus and magnesium metabolism disorders, cardiovascular system manifestations such as high blood pressure and left ventricular hypertrophy, and gastrointestinal manifestations such as nausea and vomiting, etc., and need to consult a doctor in a timely manner. Generally speaking, uremia caused by polycystic kidney, Fabry disease, etc. has genetic predisposition, while other non-genetic causes such as primary glomerular disease, diabetic nephropathy and other causes of uremia may not have genetic predisposition. Uremia patients should go to the hospital in time for consultation and timely treatment under the guidance of professional physicians.