Cranial defects are relatively common in life and people are not unfamiliar with them. According to the survey, there are many causes of cranial defects, such as cranial trauma, brain surgery to remove bone flaps, tumor removal, and chronic osteomyelitis of the skull. After skull defect, the patient’s brain tissue loses strong protection and is exposed to atmospheric pressure, which will directly affect the normal operation of various tissues in the brain, and will also make the patient have a strong sense of inferiority due to unsightly appearance, reduce normal communication with people, and lead to a decrease in the quality of life treatment. It may also trigger adverse reactions such as dizziness and headache. Then skull repair must be performed as soon as possible after skull defect. We do not recommend flying in an airplane for people with skull defect, because we all have the experience of flying. During the flight of an airplane, with the change of flight altitude, the pressure in the cabin will have certain changes, and our eardrum will feel the change of pressure, especially during the process of taking off and landing, the pressure change is very big. Due to the lack of skull protection in the skull defect area, the surface of brain tissue is only covered by soft tissues such as skin, the pressure change in the cabin will cause certain pressure on the brain tissue in the skull defect area, and in this process if the pressure is high, it will cause certain damage to the brain tissue and even cause seizures. Therefore, it is recommended that people with cranial defects should not fly until they have undergone cranial repair for the time being.