Pemphigus elderly skin extensive ulceration, it is recommended to go to the hospital for treatment in a timely manner, and at the same time to avoid scratching, self-medication and so on. Pemphigus is an autoimmune skin disease, mainly manifested as blisters and ulcers on the skin and mucous membranes, accompanied by pain, etc., while different types of pemphigus, the patient’s clinical manifestations are also different. It is recommended to give appropriate medication under the guidance of a doctor. Patients with pemphigus should be treated with glucocorticosteroids such as prednisone and methylprednisolone as prescribed by the doctor to inhibit the immune response and reduce and improve the symptoms. Immunosuppressants such as azathioprine, methotrexate and cyclosporine A can also be used in conjunction with glucocorticoids to improve the efficacy and enhance the therapeutic effect. Human immunoglobulin and rituximab can also be used under the guidance of the doctor. If combined with bacterial infection, can apply cephalexin, cefaclor, amoxicillin and other anti-infection treatment. Patients with pemphigus will have emergency situations such as large blisters and large amounts of exudate, and in order to avoid excessive loss of body fluids and water-electrolyte disorders, they need to be admitted to the hospital in time for treatment.