There are more than 4,000 chemicals in the smoke of burning tobacco, including 69 substances that are clearly carcinogenic. And it is the nicotine in tobacco that makes smokers addicted and produces withdrawal symptoms after they stop smoking. In 1998, the World Health Organization included tobacco dependence as a disease in the International Classification of Diseases (ICD-10) (F17.2, Psychoneurological Disorders). The etiology of tobacco dependence is nicotine dependence. It manifests itself as an uncontrollable urge to seek tobacco, compulsive and continuous use of tobacco products to experience the pleasure and excitement it brings and to escape the discomfort of not having access to tobacco. Therefore, smoking is not only a habit, but more importantly a chronic, highly relapsing addictive disease, and the majority of smokers are essentially nicotine dependent patients. Nicotine is the main alkaloid in tobacco, and smoking is the most efficient way to use nicotine, with other ways of using nicotine being absorbed more slowly. Nicotine is very easily absorbed by the mucous membranes of the mouth, gastrointestinal and whistle tracts. After a paper cigarette is lit 50% of the nicotine diffuses into the air with the smoke, and about 20% enters the brain via the blood circulation within 10-20 seconds. Nicotine activates the reward center by binding to acetylcholinergic receptors (i.e., nicotinic receptors) in the brain and autonomic ganglia, resulting in a brief and rapid release of dopamine, which causes whistling excitement and increased blood pressure, making smokers feel happy, emotional relief, quick thinking, and appetite suppression. During the interval of smoking, the level of nicotine in the brain decreases, and smokers crave nicotine supplementation in order to calm their emotions and restore their sense of pleasure, triggering compulsive smoking behavior and leading to nicotine dependence. Long-term smoking leads to a decrease in nicotine receptor sensitivity. Therefore, many smokers have a tendency to increase their smoking as their smoking age increases. What are the main clinical criteria for diagnosing nicotine dependence? 1. Smoking 10-40 cigarettes/day for several weeks; 2. Tolerance; 3. Withdrawal symptoms when you stop smoking. Such as irritability, irritability, insomnia, slowed heart rate, increased desire to smoke, etc.; 4. Most addicted smokers smoke their first cigarette within half an hour of waking up in the morning. There is individual variability in the degree of nicotine dependence, and for smokers with a nicotine dependence test scale score of 4 or higher, success in quitting by will alone is extremely low. Smoking cessation is a complex process of treatment for tobacco addiction. Unlike simple physical illnesses such as pneumonia, quitting smoking is a complex process of treating tobacco addiction for nicotine addicted smokers. It is a long and, in many cases, unpleasant process. The success of quitting depends largely on: 1. the severity of the patient’s withdrawal symptoms and the efficacy of treatment; 2. the proper understanding and prevention of relapse. The euphoria and stimulation caused by addictive substances are always fresh in people’s minds, and even after a long period of cessation, the environment associated with smoking can sometimes still act as an induction to smoking through conditioning. Because the causes, clinical manifestations, and causes of relapse are multifaceted, treatment of nicotine dependence requires pharmacological treatment, psycho-behavioral treatment, and comprehensive social interventions. The judgment of the efficacy of nicotine dependence treatment is ultimately based on whether the smoking behavior has stopped, and the leading agent of behavior change must be the perpetrator. For Lao Li, making the decision to quit smoking and starting to act on it was the foundation for successful cessation. What he needed to do next was to seek help from a professional smoking cessation clinic to develop a smoking cessation plan and treatment plan that was specific to him. Smoking is like boiling a frog in warm water, once you realize the danger the danger is inevitable, it is the original sin of tobacco! Since smoking is a disease, what are you waiting for? Cure the disease before it’s too late!