Whether it is Chinese herbal medicine, proprietary Chinese medicine or western medicine, all of them may cause liver damage, and in serious cases, they may cause liver insufficiency or even acute liver failure, which may endanger patients’ lives. Common liver-injuring Chinese medicines mainly include bitter almond, cassava, broad bean root, northern bean root, mugwort, mao dongqing, toadstool, leigong vine, he shou wu, etc.; common Chinese medicines include strong bone and joint pills, gerbera soup, tianma pill, niuhuang detoxification tablets, wet poison clear, etc.; common liver-injuring Western medicines mainly include acetaminophen, pau taisong, ibuprofen, chloramphenicol, tetracycline, cimetidine, amiodarone, fenofibrate, simvastatin, Gliclazide, etc. These drugs may cause drug-related liver damage if taken in excess or for too long. Therefore, the first thing is to strictly follow the doctor’s instructions, and if necessary, regularly monitor the liver function to decide whether to continue taking the drug or whether to reduce the dosage. When drug-related liver damage occurs clinically, it is necessary to stop taking the drug while actively applying liver-protective and enzyme-lowering drugs for treatment, and in severe cases, artificial liver or even liver transplantation may be required.