Toe stitches rot is mainly due to fungal infection, can be treated with topical antifungal drugs or oral medication. Topical drugs can choose ketoconazole emulsion or terbinafine gel, which need to be repeated several times. If accompanied by bacterial infection can be applied with topical fusidic acid or mupirocin ointment. If necessary, according to the patient’s specific physical condition, oral antifungal drugs such as terbinafine and itraconazole can be used for treatment, and the patient’s liver and kidney functions need to be monitored to prevent liver and kidney damage. In the process of treatment, patients must pay attention to personal hygiene and cleanliness, especially the feet should be kept dry, do not often exercise, do not wear closed foot covering shoes, sweating will aggravate the patient’s symptoms. Drugs are used in accordance with medical advice.