Bilirubin three exceeds three times the normal value, we should actively find the cause, targeted treatment, such as: drug treatment, surgical treatment, etc., and pay attention to adjust the lifestyle and diet. 1. Find the cause: Bilirubin refers to total bilirubin, direct bilirubin and indirect bilirubin. If the values of these three items are high and more than three times of the normal value, the patient may have diseases of the liver and biliary system, such as: viral hepatitis, cirrhosis of the liver, etc., which affects the conversion and metabolism of bilirubin; bile duct stones, bile duct obstruction, and other diseases that affect the bilirubin excretion. To further clarify the diagnosis through liver and gallbladder ultrasound, CT and other examinations. 2. Targeted treatment: patients can take anti-inflammatory choleretic tablets, compound glycyrrhizin and other drugs for hepatobiliary treatment. If combined with viral hepatitis, antiviral treatment should be carried out under the evaluation of doctors, such as: entecavir, tenofovir and so on. If the symptoms are more serious, such as bile duct stones leading to severe obstruction of the common bile duct, surgery is needed to remove the stones and relieve the obstruction. 3. Adjust the lifestyle and diet: usually eat a light diet, do not eat too greasy and spicy food, so as not to aggravate the burden on the digestive system and aggravate the condition. Don’t smoke and drink alcohol, have a regular routine and keep a good mood. The above drugs should be taken under the guidance of a clinician to avoid adverse reactions.