In our clinical work, we found that both computer-assisted binocular indirect ophthalmoscopic imaging system and RetCam were used for fundus examination of preterm infants, and both tools had their advantages and disadvantages. 100% sensitivity and 96% specificity of RetCam for screening high-risk ROP (zone 1 or stage 3 or with additional lesions) were achieved by Ells et al. The domestic study by Haidong Shan et al. also agreed with the above statement, and also concluded that the accuracy of RetCam in diagnosing peripheral and stage 1 and 2 ROP was not satisfactory. For the computer-assisted binocular indirect ophthalmoscopic imaging system, although the imaging clarity of posterior pole retinal ROP lesions is not as good as that of RetCam, it has certain advantages for the diagnosis of peripheral retinal ROP lesions, especially in the ROP II or III area, and most of the early ROP lesions are in the peripheral area, and the detection of early lesions is the key to gaining the initiative of treatment. The combined use of a computer-assisted binocular indirect ophthalmoscopic imaging system and RetCam for fundus examination of preterm infants was found to help improve the diagnostic rate of ROP, as well as facilitate objective data preservation and ROP screening training.