Malignant staphyloma is medically known as erosive staphyloma, also known as invasive staphyloma, malignant staphyloma is a term from the past. malignant staphyloma and choriocarcinoma are both belong to the category of malignant tumors, which belong to different branches of gestational trophoblastic tumors. The main differences between malignant staphyloma and choriocarcinoma are as follows: I. Source: both are related to pregnancy.1. Malignant staphyloma only originates from staphyloma, and pre-term pregnancy is the process of staphyloma.2. Choriocarcinoma has a wider range, and it can be originated from staphyloma, and can also be originated from other pregnancies, such as full-term birth, pre-term labor, miscarriage, and ectopic pregnancy, etc.3 II. Degree of malignancy: malignant staphyloma is comparatively lower in degree of malignancy than choriocarcinoma. Malignant degree: compared with choriocarcinoma, malignant staphylocarcinoma has low malignant degree, so the metastatic site is less; 3. Pathological diagnosis: pathology is the gold standard for diagnosing malignant tumors.1, malignant staphylocarcinoma has typical structure of chorionic villi.2, choriocarcinoma disappears chorionic villi structure, which mainly manifests as large area of necrosis and bleeding. Malignant hyperemesis gravidarum and choriocarcinoma are difficult to distinguish, if there is no way to differentiate between the same principles of diagnosis and treatment of the disease, the application of drugs is also relatively close to the public, the difference is not particularly important. For gestational trophoblast, there are not many opportunities to obtain pathology, and most of the disease diagnosis mainly relies on clinical diagnosis, so clinicians are required to strictly grasp to prevent misdiagnosis and mistreatment.