Feel very tired, very tired may be physiological factors, there may be pathological factors such as chronic hepatitis nephritis, hypothyroidism and depression. 1. Physiological factors: too much tension at work, often stay up late, irregular work and rest, no time for exercise, long-term fatigue this sub-healthy state will feel very tired, very tired. Then adjust your mindset, regular work and rest, appropriate exercise, sleep, generally will be relieved. 2. Disease causes: (1) chronic hepatitis nephritis, hypothyroidism: liver and kidney function tests to see if there is chronic hepatitis or chronic nephritis, as well as thyroid function tests, hypothyroidism is generally the symptoms of these patients are fatigue, weakness, lethargy and so on. (2) depression: anxiety, depression and other psychiatric disorders, chronic insomnia, day and night, depressed mood can also lead to very tired, very tired. Patients who always feel very tired and fatigue, if the rest does not relieve, it is recommended to go to the hospital in time to follow the doctor’s instructions for targeted treatment.